![]() At the 29th day, blood is collected from retro orbital vessel to measure the serum creatinine levels. The sample were 20 Wistar rats, randomized into 4 groups: control group, a group receiving paracetamol 32 mg/kg body weight, a group receiving codeine 1,9 mg/kg body weight, and a group receiving paracetamol 32 mg/kg body weight and codeine 1,9 mg combination, administered 4 times a day orally using gastric instillation for 28 days. ![]() However, these drugs also have potential side effect on the kidney.Methods : An experimental study of post-test only control group design. ![]() Combination of these drugs give a better potential in pain management. They belong to different group of analgesic and have different mechanism of action. Combination of paracetamol and codeine is an alternative analgesic combination in chronic pain management. ![]() Background : Pain is one of the most common complaint in patients.
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